Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 4/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | TPMT | P51580 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30601660 | 0.86 | HDAC1 (0.48) | ACP1TTRALDH1A1HPGDGAA | |
| SCHEMBL26626630 | 0.86 | HDAC1 (0.48) | ACP1TTRALDH1A1HPGDGAA | |
| SCHEMBL11818428 | 0.80 | APEX1 (0.41) | TTRALDH1A1TSHRGSK3BTPMT | |
| SCHEMBL27101413 | 0.78 | CA5A (0.48) | ACP1TTRALDH1A1HPGDGAA | |
| SCHEMBL1191845 | 0.78 | TTR (0.62) | TTRALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL11731338 | 0.78 | TTR (0.39) | TTRALDH1A1TSHRGSK3BTPMT | |
| SCHEMBL1071876 | 0.78 | TTR (0.62) | ACP1TTRALDH1A1HPGDKMT2A | |
| SCHEMBL7084456 | 0.76 | GSK3B (0.57) | TTRALDH1A1GAATSHRGSK3B | |
| SCHEMBL987177 | 0.76 | TTR (0.38) | TTRALDH1A1HPGDTSHRGSK3B | |
| SCHEMBL1003817 | 0.76 | TSHR (0.53) | ACP1TTRALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12606566-B2 | Substituted cyclopenta[4,5]pyrrolo[1,2-a]pyrazines as bruton's tyrosine kinase inhibitors | SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD. (CN) | 2026-04-21 | — | — | US | disclosed |
| US-20240067659-A1 | METHOD FOR PREPARING HETEROCYCLIC DERIVATIVE COMPOUND, COMPOSITION CONTAINING SAME COMPOUND, AND HYDRATE OF SAME COMPOUND | JW PHARMACEUTICAL CORPORATION (KR) | 2024-02-29 | — | — | US | disclosed |
| US-20230348471-A1 | BRUTON'S TYROSINE KINASE INHIBITOR AND PREPARATION METHOD THEREFOR | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. (CN) | 2023-11-02 | — | — | US | disclosed |
| US-20230348471-A1 | BRUTON'S TYROSINE KINASE INHIBITOR AND PREPARATION METHOD THEREFOR | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. (CN) | 2023-11-02 | — | — | US | disclosed |
| US-20230348471-A1 | BRUTON'S TYROSINE KINASE INHIBITOR AND PREPARATION METHOD THEREFOR | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. (CN) | 2023-11-02 | — | — | US | disclosed |
| CN-115715291-A | Bruton's tyrosine kinase inhibitor and preparation method thereof | 上海华汇拓医药科技有限公司 | 2023-02-24 | — | — | CN | disclosed |
| WO-2021254483-A1 | BRUTON'S TYROSINE KINASE INHIBITOR AND PREPARATION METHOD THEREFOR | 上海华汇拓医药科技有限公司 | 2021-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12606566-B2 | Substituted cyclopenta[4,5]pyrrolo[1,2-a]pyrazines as bruton's tyrosine kinase inhibitors | BTK, LYN, SYK | ACP1 18/4885TTR 2752/4885ALDH1A1 4530/4885 |
| US-20230348471-A1 | BRUTON'S TYROSINE KINASE INHIBITOR AND PREPARATION METHOD THEREFOR | BTK, SYK, LCK | ACP1 182/4885TTR 4665/4885ALDH1A1 4598/4885 |
| US-20240067659-A1 | METHOD FOR PREPARING HETEROCYCLIC DERIVATIVE COMPOUND, COMPOSITION CONTAINING SAME COMPOUND, AND HYDRATE OF SAME COMPOUND | REN, NOD1, NLRP3 | ACP1 2866/4885TTR 1146/4885ALDH1A1 1108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.