Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | PAX2 | Q02962 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24129343 | 0.75 | PAX2 (0.63) | LMNAPAX2SMN1; SMN2MAPTTSHR | |
| SCHEMBL24129395 | 0.73 | PAX2 (0.61) | LMNAPAX2SMN1; SMN2MAPTTSHR | |
| SCHEMBL24129361 | 0.72 | SMN1; SMN2 (0.48) | LMNAPAX2SMN1; SMN2MAPTTSHR | |
| SCHEMBL24129095 | 0.72 | PAX2 (0.47) | LMNAPAX2SMN1; SMN2MAPTTSHR | |
| SCHEMBL24129236 | 0.71 | PAX2 (0.63) | LMNAPAX2SMN1; SMN2MAPTTSHR | |
| SCHEMBL15688284 | 0.71 | ALDH1A1 (0.42) | LMNASMN1; SMN2MAPTTSHRALDH1A1 | |
| SCHEMBL7196374 | 0.71 | ALDH1A1 (0.40) | LMNASMN1; SMN2MAPTTSHRALDH1A1 | |
| SCHEMBL14271007 | 0.70 | KDM4E (0.51) | LMNAPAX2SMN1; SMN2MAPTTSHR | |
| SCHEMBL24129190 | 0.70 | PAX2 (0.45) | LMNAPAX2SMN1; SMN2MAPTTSHR | |
| SCHEMBL24129416 | 0.68 | SMN1; SMN2 (0.50) | LMNAPAX2SMN1; SMN2MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021257614-A1 | HETEROCYCLIC INHIBITORS OF ENPP1 | VOLASTRA THERAPEUTICS, INC. (US) | 2021-12-23 | — | — | WO | disclosed |