Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15688284 | 0.76 | ALDH1A1 (0.42) | ALDH1A1KDM4EHSD17B10MAPK1PKM | |
| SCHEMBL9770306 | 0.76 | ALDH1A1 (0.42) | ALDH1A1KDM4EGAAPOLBEGLN2 | |
| SCHEMBL10594859 | 0.76 | ALDH1A1 (0.40) | ALDH1A1KDM4EHSD17B10MAPK1PKM | |
| SCHEMBL9785829 | 0.72 | EGLN2 (0.41) | ALDH1A1KDM4EHPGDPOLBEGLN2 | |
| SCHEMBL9490199 | 0.71 | ALDH1A1 (0.51) | ALDH1A1KDM4EHSD17B10MAPK1PKM | |
| SCHEMBL19390791 | 0.71 | ALDH1A1 (0.43) | ALDH1A1KDM4EHSD17B10MAPK1HPGD | |
| SCHEMBL5199168 | 0.71 | TSHR (0.50) | ALDH1A1KDM4EHSD17B10MAPK1PKM | |
| SCHEMBL24129397 | 0.71 | LMNA (0.42) | ALDH1A1KDM4EHSD17B10MAPK1HPGD | |
| SCHEMBL7096531 | 0.69 | ALDH1A1 (0.48) | ALDH1A1KDM4EMAPK1HPGDTSHR | |
| SCHEMBL10876049 | 0.69 | L3MBTL1 (0.41) | ALDH1A1KDM4EHSD17B10MAPK1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180200253-A1 | Heteroaromatic Compounds and their Use as Dopamine D1 Ligands | PFIZER INC. (US) | 2018-07-19 | — | — | US | disclosed |
| US-20180200253-A1 | Heteroaromatic Compounds and their Use as Dopamine D1 Ligands | PFIZER INC. (US) | 2018-07-19 | — | — | US | disclosed |
| US-20180200253-A1 | Heteroaromatic Compounds and their Use as Dopamine D1 Ligands | PFIZER INC. (US) | 2018-07-19 | — | — | US | disclosed |
| EP-3323821-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | Pfizer Inc (US) | 2018-05-23 | — | — | EP | disclosed |
| EP-2917219-B1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER (US) | 2017-09-27 | — | — | EP | disclosed |
| EP-2917219-B1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER (US) | 2017-09-27 | — | — | EP | disclosed |
| US-20170165270-A1 | Heteroaromatic Compounds and their Use as Dopamine D1 Ligands | PFIZER INC. (US) | 2017-06-15 | — | — | US | disclosed |
| US-20170165270-A1 | Heteroaromatic Compounds and their Use as Dopamine D1 Ligands | PFIZER INC. (US) | 2017-06-15 | — | — | US | disclosed |
| US-20170165270-A1 | Heteroaromatic Compounds and their Use as Dopamine D1 Ligands | PFIZER INC. (US) | 2017-06-15 | — | — | US | disclosed |
| US-9617275-B2 | Heteroaromatic compounds and their use as dopamine D1 ligands | PFIZER INC. (US) | 2017-04-11 | — | — | US | disclosed |
| US-5322766-A | Having at least two silver halide emulsion layers sensitive to different spectral regions, at least one of high tabularity | EASTMAN KODAK COMPANY (US) | 1994-06-21 | — | — | US | disclosed |
| US-5286619-A | Containing water soluble polymer | KONICA CORPORATION (JP) | 1994-02-15 | — | — | US | disclosed |
| US-5229260-A | Pyridinium hardener for hydrophilic colloid layer | KONICA CORPORATION (JP) | 1993-07-20 | — | — | US | disclosed |
| US-5219715-A | Developing, bleaching, fixing color negative recording material having two silver halide emulsion units sensitive to different spectral regions, including a thin layer of high tabularity and low silver coverage | EASTMAN KODAK COMPANY (US) | 1993-06-15 | — | — | US | disclosed |
| US-5124230-A | Containing nucleation agent | FUJI PHOTO FILM CO., LTD. (JP) | 1992-06-23 | — | — | US | disclosed |
| EP-0447534-A1 | COLOR PHOTOGRAPHIC RECORDING MATERIAL. | EASTMAN KODAK CO (US) | 1991-09-25 | — | — | EP | disclosed |
| WO-1991006037-A1 | COLOR PHOTOGRAPHIC RECORDING MATERIAL | EASTMAN KODAK COMPANY (US) | 1991-05-02 | — | — | WO | disclosed |
| EP-0077172-B1 | A METHOD FOR FORMING A DIRECT POSITIVE COLOR IMAGE | KONICA CORPORATION (JP) | 1986-07-02 | — | — | EP | disclosed |
| EP-0116428-A2 | Silver halide photographic light-sensitive material | KONICA CORPORATION (JP) | 1984-08-22 | — | — | EP | disclosed |
| US-4444871-A | FOGGING EXPOSURE APPLIED IN WET CONDITION WITH FLUORESCENT WHITENING AGENT-CONTAINING SOLUTION | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1984-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180200253-A1 | Heteroaromatic Compounds and their Use as Dopamine D1 Ligands | COMT, DRD2, NR3C1 | ALDH1A1 2144/4885KDM4E 3804/4885HSD17B10 337/4885 |
| US-20170165270-A1 | Heteroaromatic Compounds and their Use as Dopamine D1 Ligands | ARRB1, DRD3, ADRB1 | ALDH1A1 3584/4885KDM4E 4598/4885HSD17B10 1051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.