Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.35 |
| ▸ | MEN1 | O00255 | 5/20 | 0.35 |
| ▸ | NQO1 | P15559 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22434659 | 0.82 | L3MBTL1 (0.41) | L3MBTL1KMT2AMEN1NQO1LMNA | |
| SCHEMBL24136189 | 0.82 | MEN1 (0.35) | KMT2AMEN1NQO1LMNAALDH1A1 | |
| SCHEMBL24136184 | 0.78 | CYP11B1 (0.33) | — | |
| SCHEMBL24136167 | 0.77 | IMPDH2 (0.37) | KMT2AMEN1NQO1LMNAALDH1A1 | |
| SCHEMBL22434669 | 0.70 | CYP19A1 (0.40) | L3MBTL1KMT2AMEN1NQO1LMNA | |
| SCHEMBL24136206 | 0.69 | CYP19A1 (0.35) | KMT2AMEN1LMNAALDH1A1MAPT | |
| SCHEMBL22434781 | 0.68 | CYP19A1 (0.37) | L3MBTL1KMT2AMEN1NQO1GAA | |
| SCHEMBL24136191 | 0.67 | L3MBTL1 (0.34) | L3MBTL1KMT2ANQO1LMNAALDH1A1 | |
| SCHEMBL24136162 | 0.66 | CYP11B1 (0.35) | — | |
| SCHEMBL24136153 | 0.66 | PDE2A (0.35) | IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3928836-A1 | N-SUBSTITUTED INDOLE DERIVATIVES AS PGE2 RECEPTOR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2021-12-29 | — | — | EP | disclosed |