Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | RIN1 | Q13671 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 6/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | XDH | P47989 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31481218 | 0.60 | — | — | |
| SCHEMBL9723069 | 0.55 | HPGD (0.44) | ALDH1A1PARP1PDPK1 | |
| SCHEMBL1720839 | 0.54 | ALDH1A1 (0.40) | ALDH1A1PARP1SMN1; SMN2PDPK1CA12 | |
| SCHEMBL22139858 | 0.54 | HPGD (0.44) | ALDH1A1PARP1SMN1; SMN2PDPK1CA12 | |
| SCHEMBL8343162 | 0.54 | ATIC (0.33) | — | |
| Hypoxanthine SCHEMBL25381 | 0.54 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2PDPK1LMNATSHR | |
| Hypoxanthine SCHEMBL30096461 | 0.54 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2PDPK1LMNATSHR | |
| Hypoxanthine SCHEMBL7037918 | 0.54 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2PDPK1LMNATSHR | |
| SCHEMBL8507626 | 0.53 | HPGD (0.43) | ALDH1A1ABL1PARP1PDPK1 | |
| SCHEMBL4781198 | 0.53 | ALDH1A1 (0.39) | ALDH1A1ABL1PARP1SMN1; SMN2PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4171571-B1 | TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2024-10-30 | — | — | EP | disclosed |
| US-20240352033-A1 | TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2024-10-24 | — | — | US | disclosed |
| US-11891403-B2 | Tetrazole derivatives as TRPA1 inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2024-02-06 | — | — | US | disclosed |
| CN-116157130-A | Tetrazole derivatives as TRPA1 inhibitors | 勃林格殷格翰国际有限公司 | 2023-05-23 | — | — | CN | disclosed |
| US-20210403482-A1 | TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2021-12-30 | — | — | US | disclosed |
| US-20210403482-A1 | TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2021-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11891403-B2 | Tetrazole derivatives as TRPA1 inhibitors | TRPA1, TRPV1, TRPV5 | ALDH1A1 1326/4885ABL1 2104/4885RIN1 2741/4885 |
| US-20210403482-A1 | TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS | TRPA1, TRPV1, TRPV5 | ALDH1A1 1326/4885ABL1 2104/4885RIN1 2741/4885 |
| US-20240352033-A1 | TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS | TRPA1, TRPV1, TRPV5 | ALDH1A1 1326/4885ABL1 2104/4885RIN1 2741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.