Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFATC1 | O95644 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 4/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | IGF1R | P08069 | 3/20 | 0.43 |
| ▸ | FLT4 | P35916 | 3/20 | 0.43 |
| ▸ | NR1D1 | P20393 | 5/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24144070 | 0.88 | HTR6 (0.54) | DYRK1ASERPINE1CYP19A1KDREGFR | |
| SCHEMBL24144502 | 0.88 | CYP19A1 (0.47) | GSK3BCYP19A1KDREGFRIGF1R | |
| SCHEMBL24143540 | 0.88 | NR1D1 (0.42) | NFATC1GSK3BDYRK1ASERPINE1NR1D1 | |
| SCHEMBL24143557 | 0.84 | CYP19A1 (0.45) | CYP19A1KDREGFRIGF1RFLT4 | |
| SCHEMBL24144386 | 0.84 | LMNA (0.45) | DYRK1ASERPINE1KDREGFRIGF1R | |
| SCHEMBL24144642 | 0.81 | NR1D1 (0.49) | NFATC1GSK3BDYRK1ASERPINE1CYP19A1 | |
| SCHEMBL24144290 | 0.81 | HTR6 (0.41) | GSK3BDYRK1ASERPINE1CYP19A1KDR | |
| SCHEMBL24144383 | 0.81 | CYP19A1 (0.49) | DYRK1ASERPINE1CYP19A1KDREGFR | |
| SCHEMBL24143743 | 0.81 | NR1D1 (0.50) | CYP19A1NR1D1HTR6 | |
| SCHEMBL24144465 | 0.79 | NR1D1 (0.48) | NR1D1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021263278-A1 | REV-ERB AGONISTS FOR THE TREATMENT OF TH17-MEDIATED INFLAMMATORY DISORDERS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-12-30 | — | — | WO | disclosed |