Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfadiazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.96 |
| ▸ | AURKA | O14965 | 1/20 | 0.96 |
| ▸ | DHFR | P00374 | 1/20 | 0.96 |
| ▸ | TSHR | P16473 | 1/20 | 0.96 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | EDNRA | P25101 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfadiazine SCHEMBL24176 | 0.98 | LMNA (1.00) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL10422849 | 0.98 | LMNA (1.00) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL30080807 | 0.98 | LMNA (1.00) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL34517 | 0.96 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL16860643 | 0.96 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL3728176 | 0.96 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL6141086 | 0.96 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL5870853 | 0.96 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL3274530 | 0.96 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL11176691 | 0.96 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100457113-C | Preparation method of bacteriostatic agent sulfadiazine cerium | XINXIANG HUAXIN PRODUCE CHEMIS (CN) | 2009-02-04 | — | — | CN | claimed |
| CN-1823790-A | Preparation method of bacteriostatic agent sulfadiazine cerium | HUAXIN BIOCHEMICAL MEDICAL DRE (CN) | 2006-08-30 | — | — | CN | claimed |
| CN-106907333-A | A kind of microchannel cooling air conditioning pump | 浙江贝德泵业有限公司 | 2017-06-30 | — | — | CN | disclosed |
| CN-100457113-C | Preparation method of bacteriostatic agent sulfadiazine cerium | XINXIANG HUAXIN PRODUCE CHEMIS (CN) | 2009-02-04 | — | — | CN | disclosed |
| CN-100457113-C | Preparation method of bacteriostatic agent sulfadiazine cerium | XINXIANG HUAXIN PRODUCE CHEMIS (CN) | 2009-02-04 | — | — | CN | disclosed |
| CN-1823790-A | Preparation method of bacteriostatic agent sulfadiazine cerium | HUAXIN BIOCHEMICAL MEDICAL DRE (CN) | 2006-08-30 | — | — | CN | disclosed |
| CN-1823790-A | Preparation method of bacteriostatic agent sulfadiazine cerium | HUAXIN BIOCHEMICAL MEDICAL DRE (CN) | 2006-08-30 | — | — | CN | disclosed |
| US-5990381-A | A NON-ANTIGENIC ARTIFICIAL BONE OR CARTILAGE COMPRISING COLLAGEN EXTRACTED FROM A FISH AND HYDROXYAPATITE, WHEREIN THE COLLAGEN IS CHEMICAL TREATED TO ALTER ITS ANTIGENICITY; BIOCOMPATIBILITY, NO REJECTION, GOOD ADHESION TO ORGANISMS | ISE INTERNATIONAL, CO., LTD. (JP) | 1999-11-23 | — | — | US | disclosed |
| EP-0842670-A1 | Biomedical materials | Nishihara, Katsunari (JP) | 1998-05-20 | — | — | EP | disclosed |
| US-5571521-A | Composition containing silver ammonium phenytoin complex and a phenytoin and use of said composition | LASKER SIGMUND E (US) | 1996-11-05 | — | — | US | disclosed |
| US-5439903-A | Microvoidal silver diphenyl hydantoin ammonium complex for treating animal and plant tissue infections; wound healing agents, antiseptics | LASKER SIGMUND E (US) | 1995-08-08 | — | — | US | disclosed |
| EP-0151942-A1 | Diphenyl hydrantoin silver complex and uses thereof | Lasker, Sigmund E. (US) | 1985-08-21 | — | — | EP | disclosed |
| US-4522819-A | 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid and metal salts thereof useful in burn therapy | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1985-06-11 | — | — | US | disclosed |
| EP-0136768-A2 | Composition and method for treatingskin lesions | Laboratorios Biochemie De Mexico S.A. DE C.V. (MX) | 1985-04-10 | — | — | EP | disclosed |
| WO-1985001208-A1 | ANTIMICROBIAL COMPOSITIONS CONTAINING 1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-7-(1-PIPERAZINYL)-3-QUINOLINE CARBOXYLIC ACID OR METAL SALTS THEREOF AND SILVER SULFADIAZINE | RESEARCH CORPORATION (US) | 1985-03-28 | — | — | WO | disclosed |
| US-4404197-A | Antimicrobial compositions containing 1-ethyl-6-fluoro-1,4-dihydro-4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid or metal salts thereof and silver sulfadiazine | RESEARCH CORPORATION A NEW YORK NOT-FOR-PROFIT CORP | 1983-09-13 | — | — | US | disclosed |
| EP-0049593-A1 | 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid and metal salts thereof useful in burn therapy | Fox, Charles l., Jr. (US) | 1982-04-14 | — | — | EP | disclosed |
| US-4078058-A | Cerium sulfadiazine for treating burns | RESEARCH CORPORATION (US) | 1978-03-07 | — | — | US | disclosed |
| US-4078058-A | Cerium sulfadiazine for treating burns | RESEARCH CORPORATION (US) | 1978-03-07 | — | — | US | disclosed |
| US-4078058-A | Cerium sulfadiazine for treating burns | RESEARCH CORPORATION (US) | 1978-03-07 | — | — | US | disclosed |