SCHEMBL24196880

SCHEMBL24196880

CCCNSc1ccc(-c2ccccc2)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 2/20 0.40
DRD4 P21917 2/20 0.40
DRD3 P35462 2/20 0.40
HDAC1 Q13547 2/20 0.38
HDAC2 Q92769 2/20 0.38
HDAC3 O15379 1/20 0.38
HDAC8 Q9BY41 1/20 0.38
NCOR2 Q9Y618 1/20 0.38
L3MBTL1 Q9Y468 3/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
SIGMAR1 Q99720 1/20 0.38
HPGD P15428 1/20 0.38
MAPT P10636 1/20 0.36
PDE5A O76074 1/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
ALDH1A1 P00352 1/20 0.35
TAAR1 Q96RJ0 2/20 0.34
CHRNB2 P17787 1/20 0.34
CHRNB4 P30926 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22679713 0.89 HDAC1 (0.46) DRD2DRD4DRD3HDAC1HDAC2
SCHEMBL20345821 0.78 HPGD (0.39) DRD2DRD4L3MBTL1HPGDMAPT
SCHEMBL2554566 0.76 LMNA (0.44) HDAC1HDAC2HDAC3HDAC8NCOR2
SCHEMBL8604423 0.74 SIGMAR1 (0.47) SIGMAR1HPGDALDH1A1
Hydrochloric Acid SCHEMBL10395903 0.74 CYP1A2 (0.41) HDAC1HDAC2HDAC3HDAC8NCOR2
SCHEMBL23657209 0.74 PTGES (0.47) DRD2DRD4DRD3SIGMAR1NPC1
Biphenyl SCHEMBL12984111 0.72 DRD2 (0.56) DRD2DRD4DRD3HDAC1HDAC2
SCHEMBL7362589 0.70 ALDH1A1 (0.40) L3MBTL1SMN1; SMN2SIGMAR1HPGDMAPT
SCHEMBL12432111 0.69 ALDH1A1 (0.52) DRD2HDAC1HDAC2L3MBTL1SMN1; SMN2
SCHEMBL8260133 0.69 ALDH1A1 (0.48) DRD2DRD4DRD3HDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022008475-A1 INDOLE DERIVATIVES AND USES THEREOF FOR TREATING A CANCER UNIVERSITE CLAUDE BERNARD LYON 1 (FR) 2022-01-13 WO disclosed