Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 3/20 | 0.50 |
| ▸ | NOS3 | P29474 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | PHGDH | O43175 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7260909 | 0.80 | NOS1 (0.56) | NOS1NOS3LMNAHTR3ESLC22A2 | |
| SCHEMBL7260907 | 0.80 | NOS1 (0.56) | NOS1NOS3LMNAHTR3ESLC22A2 | |
| SCHEMBL3067531 | 0.79 | NOS1 (0.50) | NOS1NOS3SIGMAR1LMNAHTR3E | |
| SCHEMBL3067533 | 0.79 | NOS1 (0.50) | NOS1NOS3SIGMAR1LMNAHTR3E | |
| SCHEMBL21215364 | 0.78 | FAAH (0.47) | SIGMAR1FAAHPHGDHMGLLCA12 | |
| SCHEMBL21096030 | 0.78 | FAAH (0.47) | SIGMAR1FAAHPHGDHMGLLCA12 | |
| SCHEMBL10818009 | 0.78 | FAAH (0.47) | SIGMAR1FAAHPHGDHMGLLCA12 | |
| SCHEMBL13679367 | 0.78 | NOS3 (0.43) | NOS1NOS3SIGMAR1FAAHPHGDH | |
| SCHEMBL18904948 | 0.77 | FAAH (0.45) | NOS1NOS3SIGMAR1FAAHPHGDH | |
| SCHEMBL3911194 | 0.76 | SIGMAR1 (0.42) | NOS1NOS3SIGMAR1FAAHPHGDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148990-B1 | THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION | UNIV BERN (CH) | 2022-01-19 | — | — | EP | disclosed |