SCHEMBL2420121

SCHEMBL2420121

C[Si](Cl)(Cl)CSc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.48
MAPK1 P28482 1/20 0.48
MAOA P21397 1/20 0.42
MAOB P27338 1/20 0.42
FFAR1 O14842 1/20 0.40
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
HIF1A Q16665 1/20 0.38
SMN1; SMN2 Q16637 5/20 0.37
NPC1 O15118 4/20 0.37
RAB9A P51151 4/20 0.37
LMNA P02545 2/20 0.37
TDP1 Q9NUW8 2/20 0.37
NPSR1 Q6W5P4 1/20 0.37
MTNR1A P48039 1/20 0.36
MTNR1B P49286 1/20 0.36
MAPT P10636 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL113038 0.86 ALDH1A1 (0.52) ALDH1A1MAPK1MAOAMAOBFFAR1
SCHEMBL2420674 0.81 ALDH1A1 (0.52) ALDH1A1MAPK1MAOAMAOBFFAR1
SCHEMBL29901626 0.75 ALDH1A1 (0.57) ALDH1A1MAPK1MAOAMAOBFFAR1
SCHEMBL20383101 0.74 ALDH1A1 (0.56) ALDH1A1MAPK1MAOAMAOBFFAR1
SCHEMBL15638476 0.73 ALDH1A1 (0.48) ALDH1A1MAPK1MAOAMAOBFFAR1
SCHEMBL6054977 0.72 ALDH1A1 (0.39) ALDH1A1MAPK1MAOAMAOBFFAR1
SCHEMBL19611324 0.72 ALDH1A1 (0.43) ALDH1A1MAPK1MAOAMAOBFFAR1
SCHEMBL1956668 0.71 MAOA (0.50) ALDH1A1MAPK1MAOAMAOBFFAR1
SCHEMBL11727752 0.71 ALDH1A1 (0.46) ALDH1A1MAPK1MAOAMAOBFFAR1
SCHEMBL6055062 0.71 ALDH1A1 (0.41) ALDH1A1MAPK1MAOAMAOBFFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1705180-B1 Preparation methods of (organothiomethyl)chlorosilanes KOREA INST SCI & TECH (KR) 2011-09-14 EP disclosed
EP-1705180-A1 (Organothiomethyl)chlorosilanes and their preparation methods Korea Institute of Science and Technology (KR) 2006-09-27 EP disclosed
US-20060211876-A1 (ORGANOTHIOMETHYL)CHLOROSILANES AND THEIR PREPARATION METHODS KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2006-09-21 US disclosed
US-7109367-B1 (Organothiomethyl)chlorosilanes and their preparation methods KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2006-09-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060211876-A1 (ORGANOTHIOMETHYL)CHLOROSILANES AND THEIR PREPARATION METHODS ORC3, OXSR1, TST ALDH1A1 356/4885MAPK1 1657/4885MAOA 3778/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.