Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | GCK | P35557 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1992255 | 0.80 | ERN1 (0.40) | RAB9AKMT2AMEN1TDP1ERN1 | |
| SCHEMBL21369287 | 0.79 | HPGD (0.35) | RAB9AKDM4EPOLBATMSMN1; SMN2 | |
| SCHEMBL9285108 | 0.77 | TAS1R3 (0.40) | RAB9AKMT2AKCNH2KDM4EPOLB | |
| SCHEMBL21369193 | 0.75 | TSHR (0.43) | RAB9AKMT2AMEN1KDM4EPOLB | |
| SCHEMBL20176981 | 0.72 | MAPT (0.32) | MAPT | |
| SCHEMBL16545836 | 0.72 | KMT2A (0.40) | KMT2AMEN1ATMSMN1; SMN2TDP1 | |
| SCHEMBL28100693 | 0.72 | EPAS1 (0.36) | ERN1GCKHTT | |
| SCHEMBL19914437 | 0.71 | ALDH1A1 (0.34) | KMT2AMEN1KCNH2KDM4ESMN1; SMN2 | |
| SCHEMBL21368846 | 0.71 | MAPT (0.44) | RAB9AKMT2AMEN1KDM4ESMN1; SMN2 | |
| SCHEMBL22444978 | 0.70 | NPSR1 (0.39) | RAB9AKMT2AKDM4EPOLBATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022012622-A1 | DEGRADATION OF (EGFR) BY CONJUGATION OF EGFR INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2022-01-20 | — | — | WO | disclosed |