Sugi Predict

Sugi Predict / Compounds / SCHEMBL2422471

SCHEMBL2422471

SCHEMBL2422471

c1ccc2nc3[nH]c4ccccc4c3cc2c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 3/20 0.58
▸ NPC1 O15118 3/20 0.58
▸ RAB9A P51151 3/20 0.58
▸ TP53 P04637 2/20 0.58
▸ CASP1 P29466 2/20 0.58
▸ MAPK10 P53779 2/20 0.58
▸ CASP7 P55210 2/20 0.58
▸ SMN1; SMN2 Q16637 2/20 0.58
▸ CA5A P35218 1/20 0.51
▸ MAPT P10636 6/20 0.50
▸ ALDH1A1 P00352 4/20 0.50
▸ CYP1A2 P05177 4/20 0.50
▸ HSD17B10 Q99714 3/20 0.50
▸ CYP3A4 P08684 3/20 0.50
▸ HPGD P15428 3/20 0.50
▸ KDM4E B2RXH2 3/20 0.50
▸ CYP2C9 P11712 2/20 0.50
▸ CYP2C19 P33261 2/20 0.50
▸ TSHR P16473 2/20 0.50
▸ PDE2A O00408 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acridine SCHEMBL28191835 0.82 ALDH1A1 (0.62) POLBNPC1RAB9ATP53CASP1
SCHEMBL29883573 0.82 CA5A (0.60) POLBNPC1RAB9ATP53CASP1
SCHEMBL17274958 0.82 SMN1; SMN2 (0.53) POLBNPC1RAB9ATP53CASP1
SCHEMBL17275513 0.80 NPC1 (0.56) POLBNPC1RAB9ATP53CASP1
SCHEMBL18227086 0.79 PDE2A (0.51) NPC1RAB9ASMN1; SMN2MAPTALDH1A1
SCHEMBL19322145 0.79 ALDH1A1 (0.50) POLBNPC1RAB9ATP53CASP1
SCHEMBL4649005 0.78 SMN1; SMN2 (0.50) POLBNPC1RAB9ATP53CASP1
Acridine SCHEMBL28697329 0.78 MAPT (0.47) POLBNPC1RAB9ATP53CASP1
SCHEMBL25231690 0.76 KIF11 (0.59) POLBNPC1RAB9ATP53CASP1
Quindoline SCHEMBL30805772 0.74 NPC1 (0.58) POLBNPC1RAB9ATP53CASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260143905-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2026-05-21 — — US disclosed
CN-117987851-A Method for preparing indolo [2,3-b ] quinoline compounds by electrochemical iodine catalysis 山东第二医科大学 2024-05-07 — — CN disclosed
CN-117946104-A Preparation method of iodine-mediated indolo [2,3-b ] quinoline compound in water phase 山东第二医科大学 2024-04-30 — — CN disclosed
EP-3583104-B1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2021-06-09 — — EP disclosed
US-10923665-B2 Materials for organic electroluminescent devices MERCK PATENT GMBH (DE) 2021-02-16 — — US disclosed
EP-3110815-B1 INDOLOQUINOLONE COMPOUNDS AS ANAPLASTIC LYMPHOMA KINASE (ALK) INHIBITORS JIANGSU ASCENTAGE BIOMED DEV INC (CN) 2020-02-19 — — EP disclosed
US-20200044162-A1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2020-02-06 — — US disclosed
CN-106866527-B A kind of synthetic method of quinoline -2- imine derivative 北京大学 2019-09-06 — — CN disclosed
US-10173968-B2 Bishydrazone-based antifungal agents UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2019-01-08 — — US disclosed
US-20180009741-A1 BISHYDRAZONE-BASED ANTIFUNGAL AGENTS UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION 2018-01-11 — — US disclosed
US-20110237458-A1 DRUG DISCOVERY METHOD Keddem Bioscience Ltd. (IL) 2011-09-29 — — US disclosed
US-8019550-B2 Drug discovery method Keddem Bioscience Ltd. (IL) 2011-09-13 — — US disclosed
US-8019550-B2 Drug discovery method Keddem Bioscience Ltd. (IL) 2011-09-13 — — US disclosed
US-8019550-B2 Drug discovery method Keddem Bioscience Ltd. (IL) 2011-09-13 — — US disclosed
US-7829567-B2 Imino-indeno[1,2-c] quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same KAOHSIUNG MEDICAL UNIVERSITY (TW) 2010-11-09 — — US disclosed
EP-1540329-A4 DRUG DISCOVERY METHOD KEDDEM BIO SCIENCE LTD (IL) 2009-06-10 — — EP disclosed
US-20090111987-A1 Imino-Indeno[1,2-c] quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same KAOHSIUNG MEDICAL UNIVERSITY (TW) 2009-04-30 — — US disclosed
US-20050277117-A1 Drug discovery method KEDDEM BIO-SCIENCE LTD. (IL) 2005-12-15 — — US disclosed
EP-1540329-A1 DRUG DISCOVERY METHOD KEDDEM BIO-SCIENCE LTD. (IL) 2005-06-15 — — EP disclosed
WO-2004010136-A1 DRUG DISCOVERY METHOD KEDDEM BIO-SCIENCE LTD. (IL) 2004-01-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180009741-A1 BISHYDRAZONE-BASED ANTIFUNGAL AGENTS DPM1, ERG28, SUCLG1 POLB 2656/4885NPC1 928/4885RAB9A 3483/4885
US-20090111987-A1 Imino-Indeno[1,2-c] quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same IMPA1, IMPDH1, IPO5 POLB 1530/4885NPC1 335/4885RAB9A 559/4885
US-20260143905-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES LBR, GLRB, GLRA1 POLB 815/4885NPC1 3164/4885RAB9A 1155/4885
US-10923665-B2 Materials for organic electroluminescent devices OR10J3, L1CAM, EPCAM POLB 1900/4885NPC1 3415/4885RAB9A 2520/4885
US-10173968-B2 Bishydrazone-based antifungal agents DPM1, ERG28, SUCLG1 POLB 2656/4885NPC1 928/4885RAB9A 3483/4885
US-20200044162-A1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES OR10J3, L1CAM, EPCAM POLB 1900/4885NPC1 3415/4885RAB9A 2520/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.