Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | NPY1R | P25929 | 1/20 | 0.62 |
| ▸ | NPY2R | P49146 | 1/20 | 0.62 |
| ▸ | CTSV | O60911 | 1/20 | 0.57 |
| ▸ | CTSL | P07711 | 1/20 | 0.57 |
| ▸ | PARP1 | P09874 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | FASN | P49327 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27580822 | 0.82 | CTSV (0.53) | ALDH1A1MEN1KMT2APOLBPKM | |
| SCHEMBL10602238 | 0.82 | ALOX5 (0.59) | ALDH1A1MEN1KMT2APOLBPKM | |
| Biphenyl SCHEMBL28097866 | 0.81 | CTSV (0.70) | ALDH1A1MEN1KMT2APOLBPKM | |
| SCHEMBL10600299 | 0.80 | ALDH1A1 (0.52) | ALDH1A1MEN1KMT2APOLBPKM | |
| SCHEMBL28110480 | 0.80 | CTSV (0.60) | ALDH1A1MEN1KMT2APOLBPKM | |
| SCHEMBL9208428 | 0.80 | MEN1 (0.54) | ALDH1A1MEN1KMT2APOLBPKM | |
| SCHEMBL30312308 | 0.79 | ALDH1A1 (0.68) | ALDH1A1MEN1KMT2APOLBPKM | |
| SCHEMBL4011471 | 0.79 | ALDH1A1 (0.68) | ALDH1A1MEN1KMT2APOLBPKM | |
| SCHEMBL11986717 | 0.78 | F2 (0.63) | ALDH1A1MEN1KMT2AMAPTHPGD | |
| SCHEMBL16585681 | 0.77 | CTSV (0.57) | MEN1KMT2ACTSVCTSLPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049480-B1 | 2-ARYLINDOLE DERIVATIVES AS mPGES-1 INHIBITORS | ACRAF (IT) | 2013-10-30 | — | — | EP | disclosed |
| CN-101490000-B | 2-Arylindole derivatives as mPGEs-1 inhibitors | ACRAF | 2012-10-03 | — | — | CN | disclosed |
| US-8017644-B2 | 2-arylindole derivatives as nPGES-1 inhibitors | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2011-09-13 | — | — | US | disclosed |
| US-20090186922-A1 | 2-ARYLINDOLE DERIVATIVES AS NPGES-I INHIBITORS | AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.P.A. (IT) | 2009-07-23 | — | — | US | disclosed |
| CN-101490000-A | 2-arylindole derivatives as NPGES-1 inhibitors | ACRAF (IT) | 2009-07-22 | — | — | CN | disclosed |
| EP-2049480-A1 | 2-ARYLINDOLE DERIVATIVES AS NPGES-I INHIBITORS | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. (IT) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008006663-A1 | 2-ARYLINDOLE DERIVATIVES AS NPGES-I INHIBITORS | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2008-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186922-A1 | 2-ARYLINDOLE DERIVATIVES AS NPGES-I INHIBITORS | PTGES, NAT1, CSNK1G2 | ALDH1A1 796/4885MEN1 4607/4885KMT2A 1109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.