Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 9/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 9/20 | 0.49 |
| ▸ | PGR | P06401 | 6/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.49 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | MLNR | O43193 | 1/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6354251 | 0.84 | NR3C1 (0.67) | CYP3A4NR3C1PGRHIF1ALMNA | |
| SCHEMBL244665 | 0.83 | NR3C1 (0.66) | CYP3A4NR3C1PGRHIF1ALMNA | |
| SCHEMBL5700595 | 0.81 | NR3C1 (0.73) | CYP3A4NR3C1PGRHIF1ANR1I2 | |
| SCHEMBL409204 | 0.81 | NR3C1 (0.73) | CYP3A4NR3C1PGRHIF1ANR1I2 | |
| SCHEMBL4156578 | 0.81 | NR3C1 (0.73) | CYP3A4NR3C1PGRHIF1ANR1I2 | |
| SCHEMBL4826587 | 0.81 | NR3C1 (0.73) | CYP3A4NR3C1PGRHIF1ANR1I2 | |
| SCHEMBL4728177 | 0.81 | NR3C1 (0.73) | CYP3A4NR3C1PGRHIF1ANR1I2 | |
| SCHEMBL5495390 | 0.81 | NR3C1 (0.73) | CYP3A4NR3C1PGRHIF1ANR1I2 | |
| SCHEMBL111403 | 0.81 | NR3C1 (0.73) | CYP3A4NR3C1PGRHIF1ANR1I2 | |
| SCHEMBL4654367 | 0.81 | NR3C1 (0.73) | CYP3A4NR3C1PGRHIF1ANR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120004281-A1 | RNA Interference Mediated Inhibition of the Nerve Growth Factor Beta Chain (NGFB) Gene Expression Using Short Interfering Nucleic Acid (siNA) | MERCK SHARP & DOHME CORP (US) | 2012-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004281-A1 | RNA Interference Mediated Inhibition of the Nerve Growth Factor Beta Chain (NGFB) Gene Expression Using Short Interfering Nucleic Acid (siNA) | NGF, NGFR, BDNF | CYP3A4 4885/4885NR3C1 865/4885PGR 3717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.