SCHEMBL24238703

SCHEMBL24238703

COC(=O)C1=CCN(c2cc(F)c(C(=O)CBr)cn2)C1

nearest known ligand 0.33

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 2/20 0.33
▸ LMNA P02545 1/20 0.33
▸ CHRM2 P08172 1/20 0.33
▸ CHRM4 P08173 1/20 0.33
▸ CHRM5 P08912 1/20 0.33
▸ THRB P10828 1/20 0.33
▸ CHRM1 P11229 1/20 0.33
▸ CHRM3 P20309 1/20 0.33
▸ BLM P54132 1/20 0.32
▸ MCOLN3 Q8TDD5 1/20 0.32
▸ OPRK1 P41145 2/20 0.30
▸ CYP4F2 P78329 1/20 0.30
▸ CYP4A11 Q02928 1/20 0.30
▸ MEN1 O00255 1/20 0.30
▸ KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24238806 0.83 LMNA (0.36) MAPTLMNACHRM2CHRM4CHRM5
SCHEMBL24238815 0.82 MEN1 (0.36) MAPTLMNACHRM2CHRM4CHRM5
SCHEMBL22045138 0.75 KCNQ3 (0.41) MAPTMEN1KMT2A
SCHEMBL24238756 0.73 HRH3 (0.41) LMNACHRM2CHRM4CHRM5THRB
SCHEMBL29993409 0.73 KDM4E (0.44) MAPTLMNAOPRK1MEN1KMT2A
SCHEMBL28601758 0.73 KDM4E (0.44) MAPTLMNAOPRK1MEN1KMT2A
SCHEMBL18179213 0.63 PDGFRB (0.39) MAPTLMNAKMT2A
SCHEMBL31386217 0.63 GSK3B (0.37) MAPTLMNA
SCHEMBL7920331 0.63 KDM4E (0.49) MAPTLMNAKMT2A
SCHEMBL31444532 0.60 TSHR (0.40) MAPTLMNAOPRK1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220033396-A1 FURTHER HETEROAROMATIC COMPOUNDS HAVING ACTIVITY AGAINST RSV Janssen Sciences Ireland Unlimited Company (IE) 2022-02-03 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220033396-A1 FURTHER HETEROAROMATIC COMPOUNDS HAVING ACTIVITY AGAINST RSV VIM, MAVS, VARS1 MAPT 2447/4885LMNA 845/4885CHRM2 4063/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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