Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | GRM6 | O15303 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.45 |
| ▸ | DDX3X | O00571 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RARA | P10276 | 1/20 | 0.42 |
| ▸ | RARB | P10826 | 1/20 | 0.42 |
| ▸ | RARG | P13631 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2179717 | 0.88 | TRPM8 (0.58) | LMNAGRM6ALDH1A1CDC7TRPM8 | |
| SCHEMBL2426380 | 0.80 | TRPM8 (0.55) | ALDH1A1TRPM8DDX3XPOLBL3MBTL1 | |
| SCHEMBL25397707 | 0.77 | TRPM8 (0.58) | LMNAALDH1A1CDC7TRPM8DBF4 | |
| SCHEMBL2427248 | 0.77 | GRM6 (0.47) | LMNAGRM6ALDH1A1TRPM8POLB | |
| SCHEMBL20486119 | 0.76 | NPC1 (0.54) | CSNK2A2CSNK2A1ALOX5ALDH1A1POLB | |
| SCHEMBL2425563 | 0.76 | RAB9A (0.55) | CSNK2A2CSNK2A1ALOX5ALDH1A1L3MBTL1 | |
| SCHEMBL17212202 | 0.75 | CDC7 (0.62) | ALDH1A1CDC7DBF4KMT2A | |
| SCHEMBL26524186 | 0.75 | ALDH1A1 (0.49) | LMNAALDH1A1CDC7DBF4POLB | |
| SCHEMBL2428586 | 0.75 | ALDH1A1 (0.44) | CSNK2A2CSNK2A1ALDH1A1CDC7TRPM8 | |
| SCHEMBL8840161 | 0.74 | NPC1 (0.51) | CSNK2A2CSNK2A1ALDH1A1DDX3XPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605752-B1 | Sulfonamides for the treatment of congestive heart failure, their compositions and uses. | CYTOKINETICS INC (US) | 2011-09-14 | — | — | EP | disclosed |