Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 7/20 | 0.36 |
| ▸ | DRD5 | P21918 | 7/20 | 0.36 |
| ▸ | DRD2 | P14416 | 5/20 | 0.36 |
| ▸ | DRD3 | P35462 | 5/20 | 0.36 |
| ▸ | DRD4 | P21917 | 4/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20353868 | 0.85 | HRH3 (0.43) | HRH3 | |
| SCHEMBL26227089 | 0.82 | DRD1 (0.47) | HRH3DRD1DRD5DRD2DRD3 | |
| SCHEMBL12628112 | 0.78 | MAOA (0.55) | DRD1DRD5DRD2DRD3DRD4 | |
| SCHEMBL1619374 | 0.76 | MAOA (0.52) | ALDH1A1DRD1DRD5DRD2DRD3 | |
| SCHEMBL24931549 | 0.75 | KCNH2 (0.38) | HRH3DRD2DRD3 | |
| SCHEMBL21362950 | 0.74 | HRH3 (0.46) | HRH3DRD1DRD5DRD2DRD3 | |
| SCHEMBL25085601 | 0.74 | TMEM97 (0.38) | HRH3 | |
| SCHEMBL2741634 | 0.70 | OGA (0.43) | HRH3ALDH1A1 | |
| SCHEMBL10199349 | 0.70 | HRH3 (0.48) | HRH3ALDH1A1 | |
| SCHEMBL25814865 | 0.70 | DRD2 (0.51) | HRH3DRD1DRD5DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230250080-A1 | ENZYME INHIBITORS | KALVISTA PHARMACEUTICALS LTD (GB) | 2023-08-10 | — | — | US | disclosed |
| US-11613527-B2 | Enzyme inhibitors | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2023-03-28 | — | — | US | disclosed |
| US-20220048894-A1 | ENZYME INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2022-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230250080-A1 | ENZYME INHIBITORS | SERPINB1, KLKB1, SERPINE1 | HRH3 442/4885ALDH1A1 1622/4885DRD1 4401/4885 |
| US-11613527-B2 | Enzyme inhibitors | SERPINB1, KLKB1, SERPINE1 | HRH3 442/4885ALDH1A1 1622/4885DRD1 4401/4885 |
| US-20220048894-A1 | ENZYME INHIBITORS | SERPINB1, KLKB1, SERPINE1 | HRH3 442/4885ALDH1A1 1622/4885DRD1 4401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.