Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | HRH2 | P25021 | 7/20 | 0.44 |
| ▸ | HRH1 | P35367 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24254068 | 0.85 | SMN1; SMN2 (0.43) | SMN1; SMN2HRH2HRH1LMNAALDH1A1 | |
| SCHEMBL24253983 | 0.83 | SMN1; SMN2 (0.41) | SMN1; SMN2HRH2HRH1LMNAALDH1A1 | |
| SCHEMBL24254071 | 0.79 | LMNA (0.44) | SMN1; SMN2LMNAALDH1A1HTTKMT2A | |
| SCHEMBL24253974 | 0.77 | SMN1; SMN2 (0.45) | SMN1; SMN2LMNAALDH1A1HTTTSHR | |
| SCHEMBL24253870 | 0.69 | CYP2D6 (0.56) | SMN1; SMN2LMNAALDH1A1HTTKMT2A | |
| SCHEMBL9961434 | 0.66 | ALDH1A1 (0.50) | SMN1; SMN2HRH2HRH1LMNAALDH1A1 | |
| SCHEMBL26636294 | 0.65 | HRH2 (0.54) | HRH2HRH1 | |
| SCHEMBL3285657 | 0.65 | PPARA (0.41) | LMNAALDH1A1TSHRKDM4E | |
| SCHEMBL9819812 | 0.65 | ALDH1A1 (0.52) | HRH2HRH1LMNAALDH1A1TSHR | |
| SCHEMBL16887919 | 0.64 | HRH2 (0.53) | SMN1; SMN2HRH2HRH1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022034587-A1 | Traf2- AND Nck-INTERACTING KINASE (TNIK) INHIBITORS AND USES THEREOF | TNIK THERAPEUTICS LTD (IL) | 2022-02-17 | — | — | WO | disclosed |