Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.41 |
| ▸ | HRH2 | P25021 | 3/20 | 0.37 |
| ▸ | HRH1 | P35367 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HBB | P68871 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24254068 | 0.89 | SMN1; SMN2 (0.43) | SMN1; SMN2HRH2HRH1LMNAALDH1A1 | |
| SCHEMBL24253976 | 0.83 | SMN1; SMN2 (0.48) | SMN1; SMN2HRH2HRH1LMNAALDH1A1 | |
| SCHEMBL24254071 | 0.81 | LMNA (0.44) | SMN1; SMN2LMNAALDH1A1HTTMAPT | |
| SCHEMBL24253974 | 0.76 | SMN1; SMN2 (0.45) | SMN1; SMN2LMNAALDH1A1HTTTSHR | |
| SCHEMBL24254072 | 0.71 | TNIK (0.56) | — | |
| SCHEMBL24253870 | 0.68 | CYP2D6 (0.56) | SMN1; SMN2LMNAALDH1A1HTTMAPT | |
| SCHEMBL26636294 | 0.65 | HRH2 (0.54) | HRH2HRH1 | |
| SCHEMBL16887919 | 0.63 | HRH2 (0.53) | SMN1; SMN2HRH2HRH1LMNAALDH1A1 | |
| SCHEMBL30983899 | 0.63 | KDM4E (0.53) | HRH2HRH1ALDH1A1KDM4E | |
| SCHEMBL15265651 | 0.62 | VEGFA (0.47) | SMN1; SMN2LMNAALDH1A1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022034587-A1 | Traf2- AND Nck-INTERACTING KINASE (TNIK) INHIBITORS AND USES THEREOF | TNIK THERAPEUTICS LTD (IL) | 2022-02-17 | — | — | WO | disclosed |