Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.40 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.40 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24254071 | 0.82 | LMNA (0.44) | SMN1; SMN2MAPTNPC1RAB9ALMNA | |
| SCHEMBL24253870 | 0.78 | CYP2D6 (0.56) | SMN1; SMN2MAPTNPC1RAB9ALMNA | |
| SCHEMBL24254068 | 0.78 | SMN1; SMN2 (0.43) | SMN1; SMN2MAPTNPC1RAB9ALMNA | |
| SCHEMBL24253976 | 0.77 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPTLMNAHTTKMT2A | |
| SCHEMBL24253983 | 0.76 | SMN1; SMN2 (0.41) | SMN1; SMN2MAPTNPC1RAB9ALMNA | |
| SCHEMBL29065576 | 0.75 | KDM5C (0.42) | SMN1; SMN2MAPTHTTKMT2AMEN1 | |
| SCHEMBL14740643 | 0.74 | ALDH1A1 (0.56) | SMN1; SMN2MAPTNPC1RAB9AL3MBTL1 | |
| SCHEMBL653157 | 0.74 | CYP1A2 (0.67) | SMN1; SMN2MAPTNPC1RAB9ALMNA | |
| SCHEMBL28786999 | 0.72 | LMNA (0.53) | RAB9ALMNAKMT2AMEN1TSHR | |
| SCHEMBL30595900 | 0.72 | ADRB1 (0.55) | RAB9AKMT2AMEN1TSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022034587-A1 | Traf2- AND Nck-INTERACTING KINASE (TNIK) INHIBITORS AND USES THEREOF | TNIK THERAPEUTICS LTD (IL) | 2022-02-17 | — | — | WO | disclosed |