Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24253974 | 0.82 | SMN1; SMN2 (0.45) | LMNAALDH1A1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL24254068 | 0.81 | SMN1; SMN2 (0.43) | LMNAALDH1A1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL24253983 | 0.81 | SMN1; SMN2 (0.41) | LMNAALDH1A1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL24253976 | 0.79 | SMN1; SMN2 (0.48) | LMNAALDH1A1MAPTSMN1; SMN2HTT | |
| SCHEMBL24253870 | 0.76 | CYP2D6 (0.56) | LMNAALDH1A1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL13043643 | 0.76 | CYP2C19 (0.63) | LMNAALDH1A1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL5204514 | 0.75 | HTR1A (0.55) | ALDH1A1EPHX2 | |
| SCHEMBL23721039 | 0.75 | KDM1A (0.48) | LMNAALDH1A1MAPTKDM1ACHRM2 | |
| SCHEMBL3856804 | 0.75 | ALDH1A1 (0.52) | LMNAALDH1A1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL6581443 | 0.74 | MAPT (0.60) | LMNAALDH1A1MAPTSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022034587-A1 | Traf2- AND Nck-INTERACTING KINASE (TNIK) INHIBITORS AND USES THEREOF | TNIK THERAPEUTICS LTD (IL) | 2022-02-17 | — | — | WO | disclosed |