SCHEMBL24256526

SCHEMBL24256526

CC(C)c1nccc2sc(C#N)nc12

nearest known ligand 0.46

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PSMB8 P28062 2/20 0.46
PIK3CG P48736 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24256529 0.72 PSMB8 (0.36) PSMB8
SCHEMBL5030198 0.67 PSMB8 (0.65) PSMB8
SCHEMBL7902133 0.67 PSMB8 (0.65) PSMB8
SCHEMBL11709639 0.67 PSMB8 (0.59) PSMB8
SCHEMBL18238073 0.66 ALDH1A1 (0.32)
SCHEMBL25725201 0.65 HTT (0.32) PSMB8
SCHEMBL19131407 0.65 SLC6A2 (0.31)
SCHEMBL17211305 0.64 RAB9A (0.59) PSMB8
SCHEMBL22127190 0.64 ALDH1A1 (0.59) PSMB8
SCHEMBL23452413 0.64 PSMB8 (1.00) PSMB8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022035997-A1 IN VIVO ASSEMBLY OF ASGPR BINDING THERAPEUTICS AVILAR THERAPEUTICS, INC. (US) 2022-02-17 WO disclosed