Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 15/20 | 0.94 |
| ▸ | HPGD | P15428 | 12/20 | 0.94 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.94 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.78 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.78 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29740984 | 0.77 | ALDH1A1 (0.70) | ALDH1A1HPGDKDM4ECYP1A2CYP2D6 | |
| SCHEMBL9846227 | 0.75 | ALDH1A1 (0.93) | ALDH1A1HPGDKDM4ECYP1A2CYP2D6 | |
| SCHEMBL7271706 | 0.71 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ECYP1A2CYP2D6 | |
| SCHEMBL16935293 | 0.71 | ALDH1A1 (0.61) | ALDH1A1HPGDKDM4ECYP1A2CYP2D6 | |
| SCHEMBL16935203 | 0.70 | ALDH1A1 (0.96) | ALDH1A1HPGDKDM4ECYP1A2CYP2D6 | |
| SCHEMBL16935353 | 0.69 | ALDH1A1 (0.56) | ALDH1A1HPGDKDM4ECYP1A2CYP2D6 | |
| SCHEMBL15923482 | 0.68 | ALDH1A1 (0.63) | ALDH1A1HPGDKDM4ECYP1A2CYP2D6 | |
| SCHEMBL1694783 | 0.68 | KDM4E (0.64) | ALDH1A1HPGDKDM4ECYP1A2CYP2D6 | |
| SCHEMBL7521074 | 0.68 | PDE3B (0.58) | ALDH1A1HPGDKDM4ECYP1A2CYP2D6 | |
| SCHEMBL16935251 | 0.66 | ALDH1A1 (0.55) | ALDH1A1HPGDKDM4ECYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230365583-A1 | FUSED TRICYCLIC PYRIMIDINE-THIENO-PYRIDINE SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. | 2023-11-16 | — | — | US | disclosed |
| US-20230365583-A1 | FUSED TRICYCLIC PYRIMIDINE-THIENO-PYRIDINE SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. | 2023-11-16 | — | — | US | disclosed |
| WO-2022035806-A1 | FUSED TRICYCLIC PYRIMIDINE-THIENO-PYRIDINE SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230365583-A1 | FUSED TRICYCLIC PYRIMIDINE-THIENO-PYRIDINE SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | USP28, USP30, USP8 | ALDH1A1 1934/4885HPGD 2308/4885KDM4E 1927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.