Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19657619 | 0.83 | RIPK1 (0.37) | RIPK1HDAC6 | |
| SCHEMBL19657912 | 0.76 | CREBBP (0.41) | RIPK1CREBBPHDAC6 | |
| SCHEMBL24258489 | 0.73 | CREBBP (0.56) | CREBBP | |
| SCHEMBL19657828 | 0.69 | CREBBP (0.36) | RIPK1CREBBP | |
| SCHEMBL24258486 | 0.69 | CREBBP (0.61) | CREBBP | |
| SCHEMBL19644123 | 0.66 | CREBBP (0.53) | GPR142RIPK1CREBBP | |
| SCHEMBL27347680 | 0.65 | MAPT (0.41) | HDAC6 | |
| SCHEMBL24258482 | 0.64 | RIPK1 (0.45) | RIPK1CREBBPHDAC6 | |
| SCHEMBL19657386 | 0.64 | CREBBP (0.36) | RIPK1CREBBPHDAC6 | |
| SCHEMBL19657616 | 0.62 | HDAC6 (0.32) | RIPK1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464270-B1 | HETEROCYCLIC INHIBITORS OF CBP/EP300 AND THEIR USE IN THE TREATMENT OF CANCER | GENENTECH INC (US) | 2022-02-23 | — | — | EP | disclosed |