Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.36 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.36 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.36 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 4/20 | 0.35 |
| ▸ | IKBKB | O14920 | 3/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | LOX | P28300 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2431419 | 0.98 | ALOX15 (0.45) | ALOX15SMN1; SMN2SMYD3GNAI3GNAO1 | |
| SCHEMBL13993559 | 0.82 | ALOX15 (0.49) | ALOX15SMN1; SMN2SMYD3HRH3TSHR | |
| SCHEMBL22339879 | 0.77 | SMYD3 (0.40) | ALOX15SMYD3IKBKBEPHX2 | |
| SCHEMBL2429930 | 0.77 | GNAI3 (0.42) | ALOX15SMN1; SMN2SMYD3GNAI3GNAO1 | |
| SCHEMBL5006783 | 0.76 | ALDH1A1 (0.36) | ALOX15TSHREPHX2L3MBTL1 | |
| SCHEMBL1516954 | 0.76 | ALDH1A1 (0.50) | ALOX15SMN1; SMN2L3MBTL1 | |
| SCHEMBL695370 | 0.74 | KDM4E (0.44) | ALOX15SMN1; SMN2GNAI3GNAO1GNAI1 | |
| SCHEMBL4194787 | 0.74 | PARP1 (0.39) | ALOX15SMN1; SMN2SMYD3PARP1HRH3 | |
| SCHEMBL6946272 | 0.74 | GNAI3 (0.52) | GNAI3GNAO1GNAI1HRH3TSHR | |
| SCHEMBL24571244 | 0.73 | EPHX2 (0.40) | SMYD3GNAI3GNAO1GNAI1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021254384-A1 | NOVEL PYRIDO[2,3-D]PYRIMIDINE-7(8H)-ONE DERIVATIVE | 微境生物医药科技(上海)有限公司 | 2021-12-23 | — | — | WO | disclosed |
| CN-102171204-B | 8-substituted isoquinoline derivative and application thereof | ASAHI KASEI PHARMA CORP | 2014-08-20 | — | — | CN | disclosed |
| EP-2366699-B1 | 8-SUBSTITUTED ISOQUINOLINE DERIVATIVE AND USE THEREOF | ASAHI KASEI PHARMA CORP (JP) | 2013-08-07 | — | — | EP | disclosed |
| US-8299055-B2 | 8-substituted isoquinoline derivative and the use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2012-10-30 | — | — | US | disclosed |
| EP-2366699-A1 | 8-SUBSTITUTED ISOQUINOLINE DERIVATIVE AND USE THEREOF | Asahi Kasei Pharma Corporation (JP) | 2011-09-21 | — | — | EP | disclosed |
| US-20100261701-A1 | 8-Substituted isoquinoline derivative and the use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261701-A1 | 8-Substituted isoquinoline derivative and the use thereof | RELA, NFKBIA, NFKB2 | ALOX15 1967/4885SMN1; SMN2 3014/4885SMYD3 3290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.