Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24276958 | 0.79 | KDM4E (0.41) | KDM4ELMNAGFERALDH1A1L3MBTL1 | |
| SCHEMBL24276960 | 0.73 | KDM4E (0.41) | KDM4ELMNAGFERALDH1A1L3MBTL1 | |
| SCHEMBL24277079 | 0.71 | CYP1A2 (0.38) | KDM4ELMNAGFERALDH1A1L3MBTL1 | |
| SCHEMBL24276763 | 0.70 | LMNA (0.30) | LMNANPSR1 | |
| SCHEMBL24276951 | 0.68 | CSNK1E (0.36) | — | |
| SCHEMBL31692376 | 0.68 | LMNA (0.32) | LMNANPSR1 | |
| SCHEMBL24276772 | 0.67 | SPR (0.31) | — | |
| SCHEMBL5258122 | 0.62 | MAPK14 (0.48) | KDM4ELMNACYP1A2GRM2 | |
| SCHEMBL25546386 | 0.61 | ALDH1A1 (0.52) | KDM4ELMNAALDH1A1CYP1A2PRMT5 | |
| SCHEMBL20107885 | 0.61 | KDM4E (0.73) | KDM4ELMNAGFERALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022052958-A1 | HETEROCYCLIC GLP-1 AGONISTS | GASHERBRUM BIO, INC. (US) | 2022-03-17 | — | — | WO | disclosed |