Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 12/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | PKLR | P30613 | 1/20 | 0.50 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.45 |
| ▸ | CPT2 | P23786 | 2/20 | 0.45 |
| ▸ | CPT1A | P50416 | 2/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24286427 | 0.89 | PKM (0.50) | RORCPKMPKLRNR1H3 | |
| SCHEMBL24286444 | 0.88 | RORC (0.52) | RORCPKMPKLRNR1H3 | |
| SCHEMBL24286198 | 0.87 | RORC (0.63) | RORCPKMPKLRCPT2CPT1A | |
| SCHEMBL24286635 | 0.86 | RORC (0.53) | RORCPKMPKLRCPT2CPT1A | |
| SCHEMBL24286707 | 0.86 | RORC (0.55) | RORCPKMPKLRCPT2CPT1A | |
| SCHEMBL24286278 | 0.85 | RORC (0.51) | RORCPKMPKLRNR1H3 | |
| SCHEMBL24286917 | 0.85 | PKM (0.46) | RORCPKMPKLRNR1H3 | |
| SCHEMBL24286281 | 0.84 | PKM (0.49) | RORCPKMPKLRNR1H3CPT2 | |
| SCHEMBL24287119 | 0.84 | PKM (0.49) | RORCPKMPKLRNR1H3CYP11B1 | |
| SCHEMBL24286566 | 0.84 | RORC (0.57) | RORCPKMPKLRNR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307738-B1 | ARYL DIHYDRO-2H-BENZO[B][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORY AND THE TREATMENT OF DISEASE | UNIV MICHIGAN REGENTS (US) | 2022-04-20 | — | — | EP | disclosed |