Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | PKLR | P30613 | 2/20 | 0.49 |
| ▸ | RORC | P51449 | 14/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CPT2 | P23786 | 1/20 | 0.40 |
| ▸ | CPT1A | P50416 | 1/20 | 0.40 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24286278 | 0.94 | RORC (0.51) | PKMPKLRRORCNR1H3NR1H2 | |
| SCHEMBL24286427 | 0.86 | PKM (0.50) | PKMPKLRRORCNR1H3NR1H2 | |
| SCHEMBL24287119 | 0.85 | PKM (0.49) | PKMPKLRRORCNR1H3NR1H2 | |
| SCHEMBL24286222 | 0.85 | RORC (0.53) | PKMPKLRRORC | |
| SCHEMBL24286273 | 0.84 | RORC (0.51) | PKMPKLRRORCNR1H3CPT2 | |
| SCHEMBL24286271 | 0.82 | PKM (0.54) | PKMPKLRRORCNR1H3NR1H2 | |
| SCHEMBL24286917 | 0.82 | PKM (0.46) | PKMPKLRRORCNR1H3NR1H2 | |
| SCHEMBL24286337 | 0.81 | RORC (0.65) | PKMPKLRRORC | |
| SCHEMBL24286493 | 0.81 | RORC (0.63) | PKMPKLRRORC | |
| SCHEMBL24286699 | 0.80 | PKM (0.53) | PKMPKLRRORCNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307738-B1 | ARYL DIHYDRO-2H-BENZO[B][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORY AND THE TREATMENT OF DISEASE | UNIV MICHIGAN REGENTS (US) | 2022-04-20 | — | — | EP | disclosed |