Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | PKLR | P30613 | 1/20 | 0.49 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.44 |
| ▸ | RORC | P51449 | 10/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24286278 | 0.86 | RORC (0.51) | PKMPKLRNR1H3RORCHTT | |
| SCHEMBL24286281 | 0.85 | PKM (0.49) | PKMPKLRNR1H3RORCHTT | |
| SCHEMBL24286427 | 0.84 | PKM (0.50) | PKMPKLRNR1H3RORCNR1H2 | |
| SCHEMBL24286273 | 0.84 | RORC (0.51) | PKMPKLRNR1H3RORCPOLB | |
| SCHEMBL24286236 | 0.84 | PKM (0.52) | PKMPKLRNR1H3RORCL3MBTL1 | |
| SCHEMBL24286271 | 0.82 | PKM (0.54) | PKMPKLRNR1H3RORCSCN9A | |
| SCHEMBL24286917 | 0.80 | PKM (0.46) | PKMPKLRNR1H3RORCNR1H2 | |
| SCHEMBL24286444 | 0.80 | RORC (0.52) | PKMPKLRNR1H3RORCL3MBTL1 | |
| SCHEMBL24286425 | 0.80 | PKM (0.49) | PKMPKLRNR1H3RORCKMT2A | |
| SCHEMBL20957100 | 0.78 | RORC (0.69) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307738-B1 | ARYL DIHYDRO-2H-BENZO[B][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORY AND THE TREATMENT OF DISEASE | UNIV MICHIGAN REGENTS (US) | 2022-04-20 | — | — | EP | disclosed |