Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 12/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | PKLR | P30613 | 2/20 | 0.42 |
| ▸ | CPT2 | P23786 | 2/20 | 0.42 |
| ▸ | CPT1A | P50416 | 2/20 | 0.42 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24286490 | 0.84 | RORC (0.49) | RORCNR1I2HTR6PKMPKLR | |
| SCHEMBL18312294 | 0.84 | RORC (0.64) | RORCNR1I2PKMPKLR | |
| SCHEMBL24286712 | 0.83 | RORC (0.50) | RORCNR1I2HTR6PKMPKLR | |
| SCHEMBL24286535 | 0.83 | CPT1A (0.51) | RORCHTR6PKMCPT2CPT1A | |
| SCHEMBL24286571 | 0.82 | RORC (0.47) | RORCNR1I2HTR6CPT2CPT1A | |
| SCHEMBL24286458 | 0.79 | RORC (0.52) | RORCNR1I2HTR6PKMPKLR | |
| SCHEMBL24286298 | 0.79 | ALDH1A1 (0.49) | RORCPKMPKLRNPC1RAB9A | |
| SCHEMBL24286502 | 0.79 | RORC (0.55) | RORCNR1I2 | |
| SCHEMBL24286568 | 0.79 | RORC (0.50) | RORCPKMPKLRNR1H3POLB | |
| SCHEMBL24286481 | 0.78 | RORC (0.57) | RORCNR1I2PKMPKLRNR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307738-B1 | ARYL DIHYDRO-2H-BENZO[B][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORY AND THE TREATMENT OF DISEASE | UNIV MICHIGAN REGENTS (US) | 2022-04-20 | — | — | EP | disclosed |