Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18419736 | 0.92 | OPRM1 (0.46) | DNM1TSHROPRM1FDPSLMNA | |
| SCHEMBL19054491 | 0.92 | OPRM1 (0.46) | DNM1TSHROPRM1FDPSLMNA | |
| SCHEMBL23618041 | 0.90 | OPRM1 (0.44) | DNM1TSHROPRM1FDPSLMNA | |
| SCHEMBL776356 | 0.88 | DNM1 (0.41) | DNM1TSHRSMN1; SMN2OPRM1ALDH1A1 | |
| SCHEMBL2954654 | 0.82 | — | — | |
| SCHEMBL10634837 | 0.80 | OPRM1 (0.50) | DNM1TSHROPRM1FDPSLMNA | |
| SCHEMBL7967931 | 0.79 | TSHR (0.39) | DNM1TSHRSMN1; SMN2OPRM1ALDH1A1 | |
| SCHEMBL7749124 | 0.78 | OPRM1 (0.48) | DNM1TSHROPRM1FDPSLMNA | |
| SCHEMBL7628846 | 0.78 | OPRM1 (0.48) | DNM1TSHROPRM1FDPSLMNA | |
| SCHEMBL10631973 | 0.78 | OPRM1 (0.48) | DNM1TSHROPRM1FDPSLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220073538-A1 | Immunoproteasome Inhibitors | PRINCIPIA BIOPHARMA INC. (US) | 2022-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220073538-A1 | Immunoproteasome Inhibitors | PSMC2, PSMB7, PSMB2 | DNM1 2462/4885TSHR 4783/4885SMN1; SMN2 1377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.