Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | BAZ2B | Q9UIF8 | 10/20 | 0.56 |
| ▸ | BAZ2A | Q9UIF9 | 10/20 | 0.56 |
| ▸ | BRD4 | O60885 | 2/20 | 0.52 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.52 |
| ▸ | BRD2 | P25440 | 1/20 | 0.52 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | FNTA | P49354 | 2/20 | 0.49 |
| ▸ | FNTB | P49356 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29412239 | 0.85 | MAPT (0.68) | TP53MAPTTHRBBAZ2BBAZ2A | |
| SCHEMBL9535179 | 0.84 | KDM4E (0.69) | TP53MAPTTHRBBAZ2BBAZ2A | |
| SCHEMBL9531095 | 0.83 | FNTA (0.69) | TP53MAPTTHRBBAZ2BBAZ2A | |
| SCHEMBL24510742 | 0.79 | BAZ2B (0.55) | TP53BAZ2BBAZ2ABRD9BRD2 | |
| SCHEMBL24283601 | 0.79 | FNTA (0.52) | TP53MAPTTHRBMEN1USP2 | |
| SCHEMBL17339106 | 0.76 | FNTA (0.60) | TP53MAPTTHRBBAZ2BBAZ2A | |
| SCHEMBL7439300 | 0.76 | BAZ2B (0.64) | TP53MAPTTHRBBAZ2BBAZ2A | |
| SCHEMBL18549629 | 0.75 | MAPT (0.50) | TP53MAPTTHRBBAZ2BBAZ2A | |
| SCHEMBL17339148 | 0.75 | ALDH1A1 (0.61) | TP53MAPTTHRBBAZ2BBAZ2A | |
| SCHEMBL8173738 | 0.74 | GABRA1 (0.56) | MAPTMEN1USP2KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022079246-A1 | NLRP3 ACTIVATORS FOR USE IN THE TREATMENT OF INFECTIOUS DISEASES OR CANCER BY ACTIVATING NLRP3 INFLAMMASOME | ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG (DE) | 2022-04-21 | — | — | WO | disclosed |