Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.32 |
| ▸ | TACR1 | P25103 | 2/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23959763 | 0.94 | TSHR (0.37) | TSHRPOLBPKMKDM4EL3MBTL1 | |
| SCHEMBL4250620 | 0.78 | CHRM2 (0.50) | TSHRPOLBKDM4EL3MBTL1CHRM2 | |
| SCHEMBL6191432 | 0.77 | ALDH1A1 (0.46) | TSHRPOLBPKML3MBTL1 | |
| SCHEMBL15329448 | 0.77 | TSHR (0.37) | TSHRPOLBPKMKDM4EL3MBTL1 | |
| SCHEMBL5014206 | 0.76 | KMT2A (0.48) | TSHRKDM4E | |
| SCHEMBL8813389 | 0.76 | TSHR (0.40) | TSHRPOLBPKMKDM4EL3MBTL1 | |
| SCHEMBL29952267 | 0.75 | ACE (0.40) | POLBL3MBTL1TACR1 | |
| SCHEMBL29952365 | 0.75 | ACE (0.40) | POLBL3MBTL1TACR1 | |
| SCHEMBL28570207 | 0.74 | L3MBTL1 (0.47) | POLBKDM4EL3MBTL1HTTTACR1 | |
| SCHEMBL8014533 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081983-A1 | INHIBITING HUMAN INTEGRIN A4B7 | MORPHIC THERAPEUTIC, INC. (US) | 2022-04-21 | — | — | WO | disclosed |