Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24307836 | 0.85 | CYP11B2 (0.41) | HTR6CYP11B2ALOX5APAKR1C3MEN1 | |
| SCHEMBL13003536 | 0.79 | LMNA (0.44) | HTR6CYP11B2LMNAAKR1C3TSHR | |
| SCHEMBL12414652 | 0.76 | HTR6 (0.40) | HTR6CYP11B2ALOX5APLMNAAKR1C3 | |
| SCHEMBL21299098 | 0.75 | AKR1C3 (0.44) | HTR6LMNAAKR1C3MEN1TSHR | |
| SCHEMBL14236720 | 0.73 | LMNA (0.49) | LMNAAKR1C3MEN1TSHRKMT2A | |
| SCHEMBL21299020 | 0.72 | HRH3 (0.55) | HTR6LMNAAKR1C3MEN1TSHR | |
| SCHEMBL31745141 | 0.71 | CYP11B2 (0.47) | HTR6CYP11B2LMNAAKR1C3ALDH1A1 | |
| SCHEMBL29640749 | 0.71 | ALDH1A1 (0.50) | HTR6LMNAAKR1C3MEN1TSHR | |
| SCHEMBL30066526 | 0.70 | SYK (0.35) | ALOX5APFEN1 | |
| SCHEMBL16542450 | 0.70 | ALDH1A1 (0.53) | LMNAAKR1C3MEN1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3585775-B1 | AZETIDINE COMPOUNDS AS GPR119 MODULATORS FOR THE TREATMENT OF DIABETES, OBESITY, DYSLIPIDEMIA AND RELATED DISORDERS | SANOFI SA (FR) | 2022-04-06 | — | — | EP | disclosed |