Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 3/20 | 0.33 |
| ▸ | CDK2 | P24941 | 4/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.32 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26806781 | 0.81 | POLB (0.37) | USP1CDK2CCNA2CCNA1CDK1 | |
| SCHEMBL29566848 | 0.81 | POLB (0.37) | USP1CDK2CCNA2CCNA1CDK1 | |
| SCHEMBL24310447 | 0.79 | USP1 (0.33) | USP1WDR48 | |
| SCHEMBL24309696 | 0.79 | HSP90AA1 (0.35) | USP1WDR48DHFR | |
| SCHEMBL24309699 | 0.77 | F2 (0.32) | — | |
| SCHEMBL24309262 | 0.76 | CDK2 (0.32) | USP1CDK2WDR48 | |
| SCHEMBL24309736 | 0.75 | CDK2 (0.32) | USP1CDK2WDR48 | |
| SCHEMBL24310509 | 0.75 | CDK2 (0.32) | USP1CDK2WDR48 | |
| SCHEMBL24309230 | 0.73 | EGFR (0.32) | — | |
| SCHEMBL24310109 | 0.70 | LMNA (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |