Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 9/20 | 0.37 |
| ▸ | CCND1 | P24385 | 7/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.37 |
| ▸ | CCND3 | P30281 | 3/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 4/20 | 0.34 |
| ▸ | FLT3 | P36888 | 3/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309743 | 0.85 | LTA4H (0.41) | CDK2LTA4HFLT3HTR3EHTR3B | |
| SCHEMBL24309788 | 0.84 | GCK (0.36) | CDK2CCNA2 | |
| SCHEMBL24310587 | 0.82 | FLT3 (0.37) | CDK2LTA4HFLT3HTR3EHTR3B | |
| SCHEMBL29566941 | 0.82 | CDK4 (0.38) | CDK4CCND1CDK2CDK1CCNB1 | |
| SCHEMBL24309695 | 0.82 | CDK4 (0.38) | CDK4CCND1CDK2CDK1CCNB1 | |
| SCHEMBL24309516 | 0.82 | FLT3 (0.35) | CDK4CCND1CDK2CCND3LTA4H | |
| SCHEMBL24309866 | 0.82 | FLT3 (0.36) | LTA4HFLT3HTR3EHTR3BADRB1 | |
| SCHEMBL24309676 | 0.82 | FLT3 (0.38) | CDK4CCND1CDK2LTA4HFLT3 | |
| SCHEMBL24309611 | 0.80 | CDK1 (0.34) | CDK4CCND1CDK2CDK1CCNB1 | |
| SCHEMBL24310582 | 0.79 | CYP1A2 (0.34) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |