Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.38 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.37 |
| ▸ | FAAH | O00519 | 3/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2430994 | 1.00 | TBXAS1 (0.41) | TBXAS1TDP1SOAT2SOAT1LMNA | |
| SCHEMBL28430631 | 0.76 | SOAT2 (0.52) | TDP1SOAT2SOAT1LMNATSHR | |
| SCHEMBL13990162 | 0.76 | HTT (0.49) | TDP1LMNATSHRALDH1A1CYP3A4 | |
| SCHEMBL4805771 | 0.74 | CNR2 (0.45) | TBXAS1CNR1CNR2SLC6A3 | |
| SCHEMBL4805780 | 0.74 | CNR2 (0.45) | TBXAS1CNR1CNR2SLC6A3 | |
| SCHEMBL18584422 | 0.73 | SOAT2 (0.40) | TBXAS1SOAT2SOAT1TSHRALDH1A1 | |
| SCHEMBL18584423 | 0.73 | SOAT2 (0.40) | TBXAS1SOAT2SOAT1TSHRALDH1A1 | |
| SCHEMBL88418 | 0.72 | GABRA1 (0.46) | TDP1LMNATSHRALDH1A1CYP3A4 | |
| SCHEMBL27760896 | 0.70 | TDP1 (0.41) | TDP1LMNATSHRALDH1A1TP53 | |
| SCHEMBL9101156 | 0.70 | ALDH1A1 (0.74) | TDP1LMNATSHRALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2550258-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | Abbvie Inc. (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119345-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2011-09-29 | — | — | WO | disclosed |