Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310383 | 0.91 | KDM5A (0.32) | KDM4EKDM5A | |
| SCHEMBL24309848 | 0.87 | IGF1R (0.32) | HTR1ADRD2HTR7HTR6 | |
| SCHEMBL24310217 | 0.87 | HTR1A (0.31) | HTR1ADRD2HTR7HTR6 | |
| SCHEMBL24310807 | 0.84 | PTGS2 (0.30) | — | |
| SCHEMBL29566633 | 0.82 | HTR1A (0.45) | KDM4EHTR1ADRD2HTR7HTR6 | |
| SCHEMBL24310362 | 0.82 | HTR1A (0.45) | KDM4EHTR1ADRD2HTR7HTR6 | |
| SCHEMBL24309378 | 0.82 | IGF1R (0.30) | — | |
| SCHEMBL24310089 | 0.81 | DRD2 (0.35) | HTR1ADRD2HTR6 | |
| SCHEMBL24309830 | 0.80 | IGF1R (0.32) | — | |
| SCHEMBL24309802 | 0.79 | MAPK14 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |