SCHEMBL24310950

SCHEMBL24310950

CN1CCN(C(N)=O)C[C@H]1C(=O)O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 1/20 0.35
MMP3 P08254 1/20 0.35
MMP7 P09237 1/20 0.35
MMP9 P14780 1/20 0.35
MMP13 P45452 1/20 0.35
AGTR2 P50052 1/20 0.34
P2RX7 Q99572 1/20 0.33
CHRM1 P11229 1/20 0.33
ACE P12821 1/20 0.33
CCR2 P41597 1/20 0.32
KCNH2 Q12809 1/20 0.32
ATM Q13315 1/20 0.32
CA1 P00915 3/20 0.32
CA2 P00918 3/20 0.32
CA4 P22748 3/20 0.32
CA9 Q16790 3/20 0.32
ALDH1A1 P00352 1/20 0.31
HTT P42858 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
PDE4B Q07343 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27617063 0.84 AGTR2 (0.36) AGTR2P2RX7CHRM1ACECCR2
SCHEMBL15451884 0.82 CYP1A2 (0.45) AGTR2P2RX7CHRM1ATM
SCHEMBL25540250 0.79 GRM2 (0.36) AGTR2P2RX7CHRM1KCNH2GRM2
SCHEMBL12490756 0.77 P2RX7 (0.33) P2RX7CHRM1CCR2KCNH2CA1
SCHEMBL2225191 0.77 P2RX7 (0.33) P2RX7CHRM1CCR2KCNH2CA1
SCHEMBL26553956 0.77 LMNA (0.36) MMP1MMP3MMP7MMP9MMP13
SCHEMBL4492046 0.76 CHRM1 (0.44) MMP1MMP3MMP7MMP9MMP13
SCHEMBL10125636 0.75 CCR2 (0.38) MMP1MMP3MMP7MMP9MMP13
SCHEMBL799809 0.75 CCR2 (0.38) MMP1MMP3MMP7MMP9MMP13
SCHEMBL25728480 0.75 CCR2 (0.38) MMP1MMP3MMP7MMP9MMP13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022052926-A1 AROMATIC ETHYLENE COMPOUND AND PREPARATION METHOD THEREFOR, AND INTERMEDIATE, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF 广州再极医药科技有限公司 2022-03-17 WO disclosed