Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 1/20 | 1.00 |
| ▸ | NSD2 | O96028 | 1/20 | 1.00 |
| ▸ | HK1 | P19367 | 1/20 | 1.00 |
| ▸ | PAX8 | Q06710 | 1/20 | 1.00 |
| ▸ | CA1 | P00915 | 12/20 | 0.49 |
| ▸ | CA2 | P00918 | 12/20 | 0.49 |
| ▸ | CA9 | Q16790 | 12/20 | 0.49 |
| ▸ | CA12 | O43570 | 10/20 | 0.49 |
| ▸ | CA7 | P43166 | 6/20 | 0.49 |
| ▸ | CA4 | P22748 | 5/20 | 0.49 |
| ▸ | CA6 | P23280 | 5/20 | 0.49 |
| ▸ | CA5A | P35218 | 5/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.49 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.49 |
| ▸ | PKM | P14618 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CA3 | P07451 | 1/20 | 0.42 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31237278 | 1.00 | TDP2 (1.00) | TDP2NSD2HK1PAX8CA1 | |
| SCHEMBL7339146 | 0.81 | TDP2 (0.67) | TDP2NSD2HK1PAX8CA1 | |
| SCHEMBL10775524 | 0.81 | TDP2 (0.67) | TDP2NSD2HK1PAX8CA1 | |
| SCHEMBL7818893 | 0.78 | TDP2 (0.64) | TDP2NSD2HK1PAX8POLB | |
| SCHEMBL7819127 | 0.78 | TDP2 (0.64) | TDP2NSD2HK1PAX8POLB | |
| SCHEMBL30003548 | 0.78 | TDP2 (0.64) | TDP2NSD2HK1PAX8POLB | |
| SCHEMBL29902406 | 0.77 | PKM (0.62) | TDP2NSD2HK1PAX8CA1 | |
| SCHEMBL6135419 | 0.76 | TDP2 (0.61) | TDP2NSD2HK1PAX8CA1 | |
| SCHEMBL7812173 | 0.75 | TDP2 (0.60) | TDP2NSD2HK1PAX8CA1 | |
| SCHEMBL7812020 | 0.75 | TDP2 (0.60) | TDP2NSD2HK1PAX8CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11732286-B2 | T5 exonuclease-based method to identify DNA topoisomerase inhibitors | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2023-08-22 | — | — | US | disclosed |
| US-11732286-B2 | T5 exonuclease-based method to identify DNA topoisomerase inhibitors | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2023-08-22 | — | — | US | disclosed |
| US-20220170070-A1 | T5 EXONUCLEASE-BASED METHOD TO IDENTIFY DNA TOPOISOMERASE INHIBITORS | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2022-06-02 | — | — | US | disclosed |
| US-20220119858-A1 | T5 EXONUCLEASE-BASED METHOD TO IDENTIFY DNA TOPOISOMERASE INHIBITORS | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2022-04-21 | — | — | US | disclosed |
| US-11268129-B1 | T5 exonuclease-based method to identify DNA topoisomerase inhibitors | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2022-03-08 | — | — | US | disclosed |