Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
| ▸ | CFB | P00751 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24654724 | 0.88 | PSEN1 (0.39) | CYP17A1JAK2JAK3PSEN1PSEN2 | |
| SCHEMBL29456545 | 0.80 | CRHBP (0.51) | HDAC6HDAC8PRMT5WDR77CFB | |
| SCHEMBL21516990 | 0.80 | CRHBP (0.51) | HDAC6HDAC8PRMT5WDR77CFB | |
| SCHEMBL24313136 | 0.77 | PRCP (0.41) | CYP17A1PRCPMAPTL3MBTL1KDM4E | |
| SCHEMBL24313222 | 0.76 | JAK2 (0.35) | CYP17A1JAK2JAK3PRCPMAPT | |
| SCHEMBL30745929 | 0.74 | HDAC6 (0.49) | HDAC6HDAC8MAPTL3MBTL1KDM4E | |
| SCHEMBL24313474 | 0.73 | PRCP (0.43) | CYP17A1PRCPMAPTLMNASMN1; SMN2 | |
| SCHEMBL20575880 | 0.71 | PRCP (0.42) | JAK2JAK3PSEN1PSEN2APH1B | |
| SCHEMBL12090442 | 0.70 | CHRNB2 (0.64) | MAPTKDM4ELMNACHRNB2CHRNA7 | |
| SCHEMBL21516330 | 0.68 | CRHBP (0.52) | MAPTL3MBTL1KDM4EHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3784666-B1 | ANTIPROLIFERATION COMPOUNDS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2022-03-16 | — | — | EP | disclosed |