Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 9/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24313136 | 0.84 | PRCP (0.41) | PRCPMAPTCYP17A1 | |
| SCHEMBL24313515 | 0.83 | CRHBP (0.50) | MAPTLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL24654742 | 0.81 | PRKDC (0.36) | CD274TP53MAPTPDE2ASIGMAR1 | |
| SCHEMBL24313458 | 0.74 | CRHBP (0.42) | MAPTSMN1; SMN2 | |
| SCHEMBL24654724 | 0.74 | PSEN1 (0.39) | PRCPMAPTCYP17A1LMNASMN1; SMN2 | |
| SCHEMBL24313221 | 0.73 | HDAC6 (0.43) | PRCPMAPTCYP17A1LMNASMN1; SMN2 | |
| SCHEMBL24654694 | 0.72 | PRCP (0.35) | PRCPCYP17A1 | |
| SCHEMBL24313222 | 0.72 | JAK2 (0.35) | PRCPMAPTCYP17A1LMNAMEN1 | |
| SCHEMBL24313097 | 0.70 | CRHBP (0.47) | MAPTSMN1; SMN2 | |
| SCHEMBL21516639 | 0.70 | CRHBP (0.40) | KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4043460-A1 | ANTIPROLIFERATION COMPOUNDS AND USES THEREOF | Merck Patent GmbH (DE) | 2022-08-17 | — | — | EP | disclosed |
| EP-3784666-B1 | ANTIPROLIFERATION COMPOUNDS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2022-03-16 | — | — | EP | disclosed |