Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24313136 | 0.80 | PRCP (0.41) | CYP17A1KDM4EMAPTL3MBTL1PRCP | |
| SCHEMBL24313221 | 0.76 | HDAC6 (0.43) | JAK2JAK3CYP17A1KDM4EMAPT | |
| SCHEMBL29456608 | 0.75 | CRHBP (0.43) | JAK2KDM4EMAPTL3MBTL1NTRK1 | |
| SCHEMBL31472394 | 0.75 | CRHBP (0.43) | JAK2KDM4EMAPTL3MBTL1NTRK1 | |
| SCHEMBL21516598 | 0.75 | CRHBP (0.43) | JAK2KDM4EMAPTL3MBTL1NTRK1 | |
| SCHEMBL24654724 | 0.74 | PSEN1 (0.39) | JAK2JAK3CYP17A1KDM4EMAPT | |
| SCHEMBL24313474 | 0.72 | PRCP (0.43) | CYP17A1MAPTPRCPMEN1KMT2A | |
| SCHEMBL9385174 | 0.71 | CHRNB2 (0.49) | MAPTLMNA | |
| SCHEMBL11273849 | 0.71 | CHRNB2 (0.49) | MAPTLMNA | |
| SCHEMBL21516627 | 0.70 | CRHBP (0.47) | JAK2KDM4EMAPTL3MBTL1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4043460-A1 | ANTIPROLIFERATION COMPOUNDS AND USES THEREOF | Merck Patent GmbH (DE) | 2022-08-17 | — | — | EP | disclosed |
| EP-3784666-B1 | ANTIPROLIFERATION COMPOUNDS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2022-03-16 | — | — | EP | disclosed |