Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | BCAT1 | P54687 | 3/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 5/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | F11 | P03951 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24313796 | 0.86 | RBP4 (0.42) | HPGDBCAT1PTGER4PTGS1PTGS2 | |
| SCHEMBL24313726 | 0.86 | PTGER4 (0.36) | HPGDPTGER4KDM4EMEN1KMT2A | |
| SCHEMBL31723099 | 0.86 | PTGER4 (0.36) | HPGDPTGER4KDM4EMEN1KMT2A | |
| SCHEMBL24313751 | 0.84 | PTGER4 (0.40) | HPGDBCAT1PTGER4PTGS1PTGS2 | |
| SCHEMBL24313906 | 0.84 | PTGER4 (0.45) | HPGDBCAT1PTGER4PTGS1PTGS2 | |
| SCHEMBL29588657 | 0.82 | KAT6A (0.36) | — | |
| SCHEMBL24314318 | 0.81 | FLT1 (0.40) | BCAT1FLT1FLT4KDR | |
| SCHEMBL24313753 | 0.81 | MEN1 (0.38) | L3MBTL1MEN1LMNAKMT2A | |
| SCHEMBL24333729 | 0.79 | HPGD (0.39) | HPGDBCAT1PTGER4F11KDM1A | |
| SCHEMBL24313774 | 0.79 | TRIM24 (0.41) | KDM4EL3MBTL1MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |