Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | IDH2 | P48735 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29588383 | 1.00 | LMNA (0.38) | LMNATRPV1FABP4RXRARXRB | |
| SCHEMBL29588250 | 0.89 | SCN9A (0.38) | P2RX4 | |
| SCHEMBL29587334 | 0.89 | KCNH2 (0.39) | LMNACNR2 | |
| SCHEMBL24314323 | 0.89 | SCN9A (0.38) | P2RX4 | |
| SCHEMBL29588713 | 0.88 | MMP2 (0.38) | TRPV1FABP4MRGPRX4MMP2P2RX4 | |
| SCHEMBL24314311 | 0.88 | MMP2 (0.38) | TRPV1FABP4MRGPRX4MMP2P2RX4 | |
| SCHEMBL24314184 | 0.88 | ALDH1A1 (0.43) | LMNA | |
| SCHEMBL29587808 | 0.88 | ALDH1A1 (0.43) | LMNA | |
| SCHEMBL24313699 | 0.86 | SCN9A (0.35) | LMNATRPV1FABP4 | |
| SCHEMBL29587622 | 0.86 | SCN9A (0.35) | LMNATRPV1FABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |