Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4801595 | 0.89 | P2RX7 (0.40) | SMN1; SMN2CYP1A2CYP2C19P2RX7ALDH1A1 | |
| SCHEMBL3936899 | 0.83 | SMN1; SMN2 (0.52) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1LMNA | |
| SCHEMBL1396182 | 0.78 | APLNR (0.46) | ATMMPOTBXAS1 | |
| SCHEMBL2399053 | 0.77 | MAPT (0.52) | SMN1; SMN2ALDH1A1LMNATBXAS1HDAC3 | |
| SCHEMBL9774 | 0.76 | SMN1; SMN2 (0.68) | SMN1; SMN2CYP1A2CYP2C19LMNA | |
| Hexanoate SCHEMBL29010706 | 0.76 | AKR1B1 (0.48) | KMT2AALDH1A1TLR8HDAC11MEN1 | |
| SCHEMBL27587862 | 0.75 | MAPT (0.55) | NAAALMNATBXAS1HDAC3HDAC4 | |
| Hydrochloric Acid SCHEMBL3513717 | 0.75 | SMN1; SMN2 (0.66) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1LMNA | |
| SCHEMBL77616 | 0.75 | HTT (0.48) | SMN1; SMN2CYP1A2P2RX7 | |
| SCHEMBL1257990 | 0.74 | P2RX7 (0.40) | SMN1; SMN2NAAAP2RX7MTNR1AHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110230428-A1 | CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | CHDI FOUNDATION, INC. | 2011-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230428-A1 | CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | KMO, KYNU, MAOA | SMN1; SMN2 958/4885CYP1A2 414/4885CYP2C19 397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.