Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 5/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.36 |
| ▸ | MTOR | P42345 | 3/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 2/20 | 0.31 |
| ▸ | ALKBH1 | Q13686 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24316434 | 0.91 | CSF1R (0.53) | CSF1RPIK3CAMTORRXFP1POLB | |
| SCHEMBL24316982 | 0.90 | CSF1R (0.48) | CSF1RPIK3CAMTORRXFP1POLB | |
| SCHEMBL24316814 | 0.88 | CSF1R (0.47) | CSF1RPIK3CAMTORRXFP1GRM5 | |
| SCHEMBL24316983 | 0.88 | CSF1R (0.46) | CSF1RPIK3CAMTORRXFP1PDE2A | |
| SCHEMBL24316448 | 0.87 | CSF1R (0.45) | CSF1RPIK3CAMTORRXFP1POLB | |
| SCHEMBL24316553 | 0.85 | CSF1R (0.46) | CSF1RPIK3CAMTORRXFP1POLB | |
| SCHEMBL24316587 | 0.85 | CSF1R (0.44) | CSF1RPIK3CAMTORRXFP1 | |
| SCHEMBL24316554 | 0.85 | CSF1R (0.42) | CSF1RPIK3CAMTORRXFP1POLB | |
| SCHEMBL24316545 | 0.83 | CSF1R (0.43) | CSF1RPIK3CAMTORRXFP1GRM5 | |
| SCHEMBL24316565 | 0.83 | CSF1R (0.44) | CSF1RPIK3CAMTORRXFP1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022057895-A1 | HETEROAROMATIC COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2022-03-24 | — | — | WO | disclosed |
| US-9585884-B2 | Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 | AUSPEX PHARMACEUTICALS, INC. (US) | 2017-03-07 | — | — | US | disclosed |