Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 3/20 | 0.45 |
| ▸ | NPBWR1 | P48145 | 4/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24316434 | 0.92 | CSF1R (0.53) | CSF1RNPBWR1PIK3CAMTORRXFP1 | |
| SCHEMBL24316814 | 0.91 | CSF1R (0.47) | CSF1RNPBWR1MCHR1PIK3CAMTOR | |
| SCHEMBL24316982 | 0.91 | CSF1R (0.48) | CSF1RNPBWR1MCHR1PIK3CAMTOR | |
| SCHEMBL24316983 | 0.89 | CSF1R (0.46) | CSF1RMCHR1PIK3CAMTORRXFP1 | |
| SCHEMBL24316437 | 0.87 | CSF1R (0.45) | CSF1RPIK3CAMTORRXFP1GRM5 | |
| SCHEMBL24316587 | 0.86 | CSF1R (0.44) | CSF1RMCHR1PIK3CAMTORRXFP1 | |
| SCHEMBL24316553 | 0.86 | CSF1R (0.46) | CSF1RPIK3CAMTORRXFP1PDE1A | |
| SCHEMBL24316551 | 0.85 | GRM5 (0.49) | CSF1RGRM5P2RX7MAOAACHE | |
| SCHEMBL24316545 | 0.84 | CSF1R (0.43) | CSF1RNPBWR1PIK3CAMTORRXFP1 | |
| SCHEMBL24316548 | 0.84 | CSF1R (0.47) | CSF1RNPBWR1MCHR1PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022057895-A1 | HETEROAROMATIC COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2022-03-24 | — | — | WO | disclosed |
| US-9585884-B2 | Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 | AUSPEX PHARMACEUTICALS, INC. (US) | 2017-03-07 | — | — | US | disclosed |