SCHEMBL24316554

SCHEMBL24316554

COc1cc(Oc2ccc3ncc(C)c(=O)n3c2)cnc1OCc1ccc(C(C)(C)C#N)cc1

nearest known ligand 0.42

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CSF1R P07333 5/20 0.42
PIK3CA P42336 5/20 0.36
MTOR P42345 4/20 0.36
PRKDC P78527 1/20 0.34
RXFP1 Q9HBX9 1/20 0.33
POLB P06746 1/20 0.30
AXL P30530 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24316439 0.91 CSF1R (0.37) CSF1RPIK3CAMTORRXFP1
SCHEMBL24316553 0.89 CSF1R (0.46) CSF1RPIK3CAMTORRXFP1POLB
SCHEMBL24316434 0.88 CSF1R (0.53) CSF1RPIK3CAMTORRXFP1POLB
SCHEMBL24316982 0.87 CSF1R (0.48) CSF1RPIK3CAMTORRXFP1POLB
SCHEMBL24316814 0.85 CSF1R (0.47) CSF1RPIK3CAMTORRXFP1
SCHEMBL24316983 0.85 CSF1R (0.46) CSF1RPIK3CAMTORRXFP1
SCHEMBL24316437 0.85 CSF1R (0.45) CSF1RPIK3CAMTORRXFP1POLB
SCHEMBL24316448 0.84 CSF1R (0.45) CSF1RPIK3CAMTORRXFP1POLB
SCHEMBL24316587 0.82 CSF1R (0.44) CSF1RPIK3CAMTORRXFP1
SCHEMBL24316660 0.81 CSF1R (0.40) CSF1RPIK3CAMTOR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022057895-A1 HETEROAROMATIC COMPOUNDS AND USES THEREOF HUTCHISON MEDIPHARMA LIMITED (CN) 2022-03-24 WO disclosed