Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | COMT | P21964 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALPG | P10696 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29539198 | 0.89 | KDM4E (0.41) | POLBRXFP1MAPTPIK3CAMTOR | |
| SCHEMBL24316556 | 0.89 | KDM4E (0.41) | POLBRXFP1MAPTPIK3CAMTOR | |
| SCHEMBL24316804 | 0.88 | KDM4E (0.35) | POLBRXFP1PIK3CAMTORKDM4E | |
| SCHEMBL24316434 | 0.80 | CSF1R (0.53) | POLBRXFP1PIK3CAMTORKDM4E | |
| SCHEMBL24316983 | 0.79 | CSF1R (0.46) | RXFP1PIK3CAMTORCSF1RMCHR1 | |
| SCHEMBL24316982 | 0.79 | CSF1R (0.48) | POLBRXFP1PIK3CAMTORKDM4E | |
| SCHEMBL24316549 | 0.79 | CSF1R (0.43) | POLBRXFP1PIK3CAMTORKDM4E | |
| SCHEMBL24316814 | 0.78 | CSF1R (0.47) | RXFP1MAPTPIK3CAMTORKDM4E | |
| SCHEMBL24316797 | 0.78 | KDM4E (0.38) | POLBMAPTPIK3CAMTORKDM4E | |
| SCHEMBL24316436 | 0.77 | KDM4E (0.37) | POLBRXFP1PIK3CAMTORKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022057895-A1 | HETEROAROMATIC COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2022-03-24 | — | — | WO | disclosed |